2011, №4

сс. 22-50

Supercritical fluid chromatography and its application to analysis and production of high purity compounds

2011, №4

сс. 22-50

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A.S. Samokhin, I.A. Revelsky, D.A. Chepelyansky, O.O. Parenago, O.I. Pokrovskiy, F.D. Lepeshkin, K.B. Ustinovich, A.I. Revelsky

Key words: supercritical fluid chromatography, pharmaceuticals, preparative SFC, SFC/MS

Principals  of supercritical fluid chromatography (SFC) and its application in various  fields are reviewed. SFC is compared to high-performance liquid chromatography  (HPLC). Fields of SFC application are considered. Special attention is paid to  the analysis of pharmaceuticals (and their impurities), biologically active  compounds and to the utilization of preparative SFC in the production of high  purity compounds. Different types of detection in SFC are discussed; special  attention is paid to the utilization of mass-spectrometric detectors in SFC.

doi:10.1134/S1990793111080100