Key words: supercritical fluid chromatography, pharmaceuticals, preparative SFC, SFC/MS
Principals of supercritical fluid chromatography (SFC) and its application in various fields are reviewed. SFC is compared to high-performance liquid chromatography (HPLC). Fields of SFC application are considered. Special attention is paid to the analysis of pharmaceuticals (and their impurities), biologically active compounds and to the utilization of preparative SFC in the production of high purity compounds. Different types of detection in SFC are discussed; special attention is paid to the utilization of mass-spectrometric detectors in SFC.
doi:10.1134/S1990793111080100