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A new approach to the comparison of original pharmaceuticals and generics, based on comparison of multidimensional impurity profiles using supercritical fluid extraction, liquid extraction and GC-MS

2011, №4

сс. 51-58

A new approach to the comparison of original pharmaceuticals and generics, based on comparison of multidimensional impurity profiles using supercritical fluid extraction, liquid extraction and GC-MS

2011, №4

сс. 51-58

A.I. Revelsky, I.N. Glazkov, Yu.S. Yashin, D.A. Chepelyansky, A.S. Samokhin, D.A. Burmykin, I.A. Revelsky

Key words: impurities in pharmaceuticals, generics, GC-MS, derivatization, supercritical fluid extraction, liquid extraction, atmospheric pressure photochemical ionization mass-spectrometry

The possibility of comparison of original pharmaceuticals and their generics, based on multidimensional profiles of impurities isolated from different samples by supercritical fluid extraction and liquid extraction and registered by gas-chromatography/mass-spectrometry with electron ionization (EI) and atmospheric pressure photochemical ionization (APPCI) is investigated. The utilization of the suggested approach allows one to increase of the number of registered impurities and, thus, to identify the authenticity of pharmaceutical samples and to compare the quality of original pharmaceuticals and their generics.

Translated article

doi:10.1134/S1990793111080094

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ГОСТ
7.0.100-2018

Ревельский, А.И. A new approach to the comparison of original pharmaceuticals and generics, based on comparison of multidimensional impurity profiles using supercritical fluid extraction, liquid extraction and GC-MS / А.И. Ревельский, И.Н. Глазков, Ю.С. Яшин [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2011. – Т. 6. – № 4. – С. 51-58.

TRANSLIT

I., A. Novyj podhod k sopostavleniyu original'nyh farmpreparatov i dzhenerikov, osnovannyj na sravnenii mnogomernyh profilej primesej s ispol'zovaniem SFE, ZHE i hromato-mass-spektrometrii / A. I. Revel'skij, I. N. Glazkov, YU. S. YAshin [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2011. – Т. 6. – № 4. – S. 51-58.

A.I. Revelsky, I.N. Glazkov, Yu.S. Yashin, D.A. Chepelyansky, A.S. Samokhin, D.A. Burmykin, I.A. Revelsky A new approach to the comparison of original pharmaceuticals and generics, based on comparison of multidimensional impurity profiles using supercritical fluid extraction, liquid extraction and GC-MS. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 51-58 (2011). https://doi.org/

A new approach to the comparison of original pharmaceuticals and generics, based on comparison of multidimensional impurity profiles using supercritical fluid extraction, liquid extraction and GC-MS

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