Supercritical fluid micronization of risperidone

2011, №4

сс. 88-102

V.N. Bagratashvili, A.M. Egorov, L.I. Krotova, A.V. Mironov, V.Ya. Panchenko, O.O. Parenago, V.K. Popov, I.A. Revelsky, P.S. Timashev, S.I. Tsypina

Key words: SCF micronization, risperidone, polymorphism

Comparative studies of supercritical fluid micro nization processes of 50-100 mm size risperidone pharmaceutical substrate using RESS and SAS approaches are performed to enhance its bioavailability in human body. Both micronization approaches allow obtaining risperidone microparticles of 5-20 mm size. SAS approach, however, is more preferable for effective risperidone micronization, since unlike RESS it doesn't cause any detectable contamination of risperidone with organic co-solvent residuals (used in these processes) and also allows obtaining risperidone microparticles of different shapes. It was revealed that SAS micronization process causes a change of risperidone polymorphous form from triclinic to monoclinic.

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doi:10.1134/S1990793112070019

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7.0.100-2018

Баграташвили, В.Н. Supercritical fluid micronization of risperidone / В.Н. Баграташвили, А.М. Егоров, Л.И. Кротова [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2011. – Т. 6. – № 4. – С. 88-102.

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N., V. Sverhkriticheskaya flyuidnaya mikronizaciya farmacevticheskoj substancii risperidon / V. N. Bagratashvili, A. M. Egorov, L. I. Krotova [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2011. – Т. 6. – № 4. – S. 88-102.

V.N. Bagratashvili, A.M. Egorov, L.I. Krotova, A.V. Mironov, V.Ya. Panchenko, O.O. Parenago, V.K. Popov, I.A. Revelsky, P.S. Timashev, S.I. Tsypina Supercritical fluid micronization of risperidone. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 88-102 (2011). https://doi.org/

Supercritical fluid micronization of risperidone

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