Key words: supercritical carbon dioxide, biodegradable polymers, SCF micronization, poly-3-hydroxybutyrate, SAS
Micronization of poly-3-hydroxybutyrate (PHB) using SAS technique with supercritical carbon dioxide as an antisolvent is studied experimentally. The possibility of PHB particle fabrication with different morphology (including hollow spheres) and predetermined sizes varied from 100 nm to 20 μm is demonstrated. The effect of various mechanisms of the formation of solid phase during the SAS micronization process onto the size and morphology of poly-3-hydroxybutyrate particles is evaluated and discussed.
doi:10.1134/S1990793113080058