Сверхкритические флюиды. Теория и практика
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2015, N2, pp. 51-59

A.M. Vorobei, O.I. Pokrovskiy, K.B. Ustinovich, L.I. Krotova, O.O. Parenago, V.V. Lunin

Effect of Solvent Type and Concentration on Size and Morphology of Arbidol Microparticles Obtained by Supercritical Antisolvent Precipitation

The possibility to obtain microparticles of arbidol using supercritical antisolvent (SAS) precipitation method is demonstrated. Non-monotonic dependence of average particle size on arbidol concentration in methanol and DMSO is observed. The position of its minimum depends on the type of used solvent. SAS technique allows one to vary the size (1.8—500 μm) and morphology of arbidol particles which can be operated by process parameters.

Key words: supercritical carbon dioxide, SCF-micronization, supercritical antisolvent precipitation, arbidol, bioavailability

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