Effect of Solvent Type and Concentration on Size and Morphology of Arbidol Microparticles Obtained by Supercritical Antisolvent Precipitation

2015, №2

сс. 51-59

A.M. Vorobei, O.I. Pokrovskiy, K.B. Ustinovich, L.I. Krotova, O.O. Parenago, V.V. Lunin

Key words: supercritical carbon dioxide, SCF-micronization, supercritical antisolvent precipitation, arbidol, bioavailability

The possibility to obtain microparticles of arbidol using supercritical antisolvent (SAS)
precipitation method is demonstrated. Non-monotonic dependence of average particle
size on arbidol concentration in methanol and DMSO is observed. The position of its
minimum depends on the type of used solvent. SAS technique allows one to vary the
size (1.8—500 μm) and morphology of arbidol particles which can be operated by
process parameters.

Translated article

doi:10.1134/S1990793116070198

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ГОСТ
7.0.100-2018

Воробей, А.М. Effect of Solvent Type and Concentration on Size and Morphology of Arbidol Microparticles Obtained by Supercritical Antisolvent Precipitation / А.М. Воробей, О.И. Покровский, К.Б. Устинович [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2015. – Т. 10. – № 2. – С. 51-59.

TRANSLIT

Vorobej, A.M. Vliyanie tipa rastvoritelya i koncentracii arbidola na razmer i morfologiyu mikrochastic, poluchennyh metodom sverhkriticheskogo antisol'ventnogo osazhdeniya / A.M. Vorobej , O.I. Pokrovskij , K.B. Ustinovich [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2015. – Т. 10. – № 2. – S. 51-59.

A.M. Vorobei, O.I. Pokrovskiy, K.B. Ustinovich, L.I. Krotova, O.O. Parenago, V.V. Lunin Effect of Solvent Type and Concentration on Size and Morphology of Arbidol Microparticles Obtained by Supercritical Antisolvent Precipitation . Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 51-59 (2015). https://doi.org/

Effect of Solvent Type and Concentration on Size and Morphology of Arbidol Microparticles Obtained by Supercritical Antisolvent Precipitation

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