Сверхкритические флюиды. Теория и практика
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2017, N1, pp. 04-14

D.Yu. Zalepugin, А.V. Maksimkin, M.V. Kiselevsky, N.A. Tilkunova, N.Yu. Anisimova, I.V. Chernyshova, T.S. Spirina, F.S. Senatov, M.I. Vlasov

Impregnation of Ultra High Density Polyethylene with Amoxicillin in Subcritical Freon Media

Because of investigation the method of impregnation of ultra high density polyethylene (UHDPE) with amoxicillin in subcritical freon R22 was developed. For the first time a possibility of polymer, impregnation with polar substance in the absence of modifier was demonstrated. Usually removal of modifiers from polymer matrix is a serious problem. Amoxicillin desorption curves (drug release) were calculated using HPLC method. Polymer samples impregnated with amoxicillin manifested antibacterial activities in relation to gram-positive and gram-negative microorganisms S. aureus, S. epidermidis, E. faecalis, B. subtilis, E. coli, that provides a perspective for using them as real models of implants for bone replacement.

Key words: impregnation, ultra high density polyethylene, amoxicillin, subcritical freon R22

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