Сверхкритические флюиды. Теория и практика
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2017, N2, pp. 60-67

D.V. Smolentsev, M.V. Gurin, A.A. Venediktov, S.V. Evdokimov, R.A. Fadeev

Method of Deep Cleaning of Ksenogenic Bone Matrix by Extraction of Lipids with Supercritical Carbon Dioxide and Evaluation of Obtained Material

An environmentally benign method for production of osteoplastic materials for reconstructive surgery based on the supercritical fluid extract with carbon dioxide is developed. The method ensures an efficient removal of li pids and li poids with minimal consumption of carbon dioxide and processing time at reduced production costs. It is optimized for the production of osteoplasty matrixes of xenogenic bone origin. The advantages of the obtained material in comparison with existing commercial analog in in vitro experiments are demonstrated.

Key words: osteoplastic material, bone block, supercritical carbon dioxide, deli pidization, bone, implants

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