2017, №3

сс. 70-81

Supercritical Fluid Treatment of Three-Dimensional Hydrogel Matrixes Synthesized from Allilchitosan Using Laser Stereolithography

2017, №3

сс. 70-81

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A.E. Lazhko, K.N. Bardakova, B.S. Shavkuta, S.N. Churbanov, M.A. Markov, T.A. Akopova, O.O. Parenago, A.M. Grigoryev, P.S. Timashev, V.V. Lunin, V.N. Bagratashvili

Key words: structured hydrogels, matrixes, laser stereolithography, supercritical carbon dioxide

Hydrogel matrix structures (matrixes) based on the allyl-substituted chitosan derivatives
are formed using the laser stereolithography. The effects of their processing in the
supercritical carbon dioxide (SC-CO2) onto the surface polarity and mechanical
characteristics are studied. It is found that such treatment of matrixes in the flow
regime increases the mechanical strength due to an efficient extraction of low molecular
weight components and oligomers from the material. In addition, the processing in the
SC-CO2 decreases the surface polarity and, as a result, improves the biocompatibility of
the material. The hydrogel matrixes treated in the SC-CO2 have no cytotoxic effect and
are prospective materials for tissue engineering.

doi:10.1134/S1990793118070072