Сверхкритические флюиды. Теория и практика
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2018, N1, pp. 64-76

A.M. Vorobei, O.I. Pokrovskiy, K.B. Ustinovich, O.O. Parenago, V.V. Lunin, A.G. Miroshnichenko

Micronization of Salbutamol Sulfate by Supercritical Antisolvent Preci pitation: Effect of Process Parameters on Size and Morphology of Obtained Particles

The applicability of the method of supercritical antisolvent preci pitation (SAS) to obtain microparticles of an anti-asthmatic salbutamol sulfate preparation suitable for the production of an inhalable dosage form is studied. Depending on the concentration of salbutamol in the starting solution, its flow rate and the pressure, spherical or needle shaped particles of 0.7 to 8.5 microns can be obtained. The dependence of the average particle size on the concentration of salbutamol in the initial solution is nonmonotonic. The conditions for the production of particles suitable in shape and size for the inhalation dosage form are determined.

Key words: supercritical antisolvent preci pitation, salbutamol, micronization, morphology, supersaturation degree

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