2018, №3

сс. 20-32

Supercritical Carbon Dioxide — a Powerful Tool for Green Biomaterial Chemistry

2018, №3

сс. 20-32

Цитировать

N.N. Veryasova, A.E. Lazhko, D.E. Isaev, E.A. Grebenik, P.S. Timashev

Key words: supercritical carbon dioxide, biomaterial processing, sterilization, decellularization, impregnation, tissue engineering

In the review, the key aspects to the modification of biocompatible materials are
described based on treatment in supercritical carbon dioxide medium. Main trends in
the area include the fabrication of three-dimensional scaffolds, sterilization of medical
devices, mammalian tissue decellularization and material impregnation with bio-active
molecules. Due to non-destructive action of the supercritical carbon dioxide medium
towards extracellular matrix’s architecture, preservation of inherent biomechanical
properties and structure of treated biomaterials, avoidance of purification and postprocessing
steps, the technique is considered as a powerful tool to solve the urgent
issues of biomaterials science.

doi:10.1134/S1990793119070236