Key words: polymorphism, conformational equilibrium, supercritical fluids
In this work the investigation of the micronized forms of ibuprofen obtained by rapid
expansion of supercritical fluid solution being at various temperatures in the range of
40—80 °C has been fulfilled. The results of scanning electron microscopy (SEМ), X-ray
powder diffraction (RSA) and differential-scanning calorimetry (DSK) allowed coming
to conclusion that the micronized form of ibuprofen obtained by RESS is the first
polymorph with partially disturbed crystalline structure with comparison to the initial
form. The defects of such structure may be the microinclusions of melted second
polymorph. Moreover the molar fraction of these defects decreases with the increase
of temperature of supercritical solution.
doi:10.1134/S1990793119070200