Micronization of Levofloxacin by RESS Method

2019, №3

сс. 71-76

E.N. Antonov, L.I. Krotova, G.V. Mishakov, V.K. Popov

Key words: supercritical fluid technologies, RESS, micronization, antibacterial drugs, levofloxacin

Micronization of anti-bacterial drug levofloxacin (LF) by the RESS method for
obtaining microparticles with high bioavailability was performed. Ethanol was used as
a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF
microparticles with characteristic sizes < 10 microns were obtained.

Translated article

doi:10.1134/S1990793120070210

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ГОСТ
7.0.100-2018

Антонов, Е.Н. Micronization of Levofloxacin by RESS Method / Е.Н. Антонов, Л.И. Кротова, Г.В. Мишаков [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2019. – Т. 14. – № 3. – С. 71-76. - DOI: 10.34984/SCFTP.2019.14.3.008

TRANSLIT

Antonov, E.N. Mikronizaciya levofloksacina metodom RESS / E.N. Antonov, L.I. Krotova, G.V. Mishakov [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2019. – Т. 14. – № 3. – S. 71-76. - DOI: 10.34984/SCFTP.2019.14.3.008

E.N. Antonov, L.I. Krotova, G.V. Mishakov, V.K. Popov Micronization of Levofloxacin by RESS Method. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 3, 71-76 (2019). https://doi.org/10.34984/SCFTP.2019.14.3.008

Micronization of Levofloxacin by RESS Method

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