E.N. Antonov, L.I. Krotova, G.V. Mishakov, V.K. Popov
Micronization of Levofloxacin by RESS Method
Micronization of anti-bacterial drug levofloxacin (LF) by the RESS method for
obtaining microparticles with high bioavailability was performed. Ethanol was used as
a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF
microparticles with characteristic sizes < 10 microns were obtained.
Key words: supercritical fluid technologies, RESS, micronization, antibacterial drugs, levofloxacin