Сверхкритические флюиды. Теория и практика
      Главная    Авторам    Редколлегия    Статьи on-line   Подписка   Контакты

 SCF-TP on-line  

2019, N3, pp. 71-76

E.N. Antonov, L.I. Krotova, G.V. Mishakov, V.K. Popov

Micronization of Levofloxacin by RESS Method

Micronization of anti-bacterial drug levofloxacin (LF) by the RESS method for obtaining microparticles with high bioavailability was performed. Ethanol was used as a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF microparticles with characteristic sizes < 10 microns were obtained.

Key words: supercritical fluid technologies, RESS, micronization, antibacterial drugs, levofloxacin


   © 2006-2007 ЗАО "ШАГ"