Сверхкритические флюиды. Теория и практика
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2019, N4, pp. 19-26

I.V. Mikushina, V.N. Tsarev, N.G. Bazarnova, M.Yu. Cheprasova, A.V. Sysoeva, A.V. Sysoev, E.Yu. Kushnir, K.V. Gensh

Preparative Separation Method Development of Salbutamol Enantiomers by Supercritical Fluid Chromatography

The paper presents the results of scaling up the supercritical chiral separation of salbutamol to a preparative scale. Chromatographic conditions have been determined, a technique for preparative separation of enantiomers by supercritical fluid chromatography has been developed, in which the content of the R-isomer of salbutamol (enantiomeric purity) is not less than 90 %, the yield of the target product is more than 30%.

Key words: salbutamol, supercritical fluid chromatography, enantiomers, scaling method


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