Key words: salbutamol, supercritical fluid chromatography, enantiomers, scaling method
The paper presents the results of scaling up the supercritical chiral separation of
salbutamol to a preparative scale. Chromatographic conditions have been determined, a
technique for preparative separation of enantiomers by supercritical fluid
chromatography has been developed, in which the content of the R-isomer of salbutamol
(enantiomeric purity) is not less than 90 %, the yield of the target product is more
than 30%.
doi:10.1134/S1990793120070143