Key words: «one-pot», aporphine alkaloids, boldine, seco-boldine, subcritical water, phenanthrene alkaloids, HPLC, NMR
A «one-pot» method was developed and studied for the production of phenanthrene
seco-boldine from the aporphine plant alkaloid boldine in a medium of subcritical
water. The effectiveness of the proposed method for producing seco-boldine in a medium
of subcritical water was studied in the temperature range from 100 to 230 °C. It has
been established that the “one-pot” technique in the environment of subcritical water
makes it possible to achieve a quantitative yield of seco-boldine in one step, without
using any catalytic additives. The structure of the obtained product was confirmed by
NMR-spectrometry and ESI MS-spectrometry. The proposed technique does not require
the use of expensive and toxic organic solvents. The time-consuming of the proposed
approach to producing seco-boldine is 30 minutes, which allows us to move on to the
development of environmentally friendly low cost technologies for the production of
seco-boldine in medium of subcritical water.
doi:10.1134/S199079312007012X