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2019, N4, pp. 42-48

L.V. Erkhova, Yu.M. Panov, N.S Gavryushenko, V.V. Zaitsev, Yu.S. Lukina, D.V. Smolentsev, K.A Vorobev, D.P. Krutko, D.A. Lemenovskii

Supercritical Treatment of Xenogenic Bone Matrix in the Process of Manufacture of Implants for Osteosynthesis

1M.V. Lomonosov Moscow State University, Department of Chemistry, Moscow, Russia 2N.N. Priorov Central Scientific Research Institute of Traumatology and Orthopedics, Moscow, Russia 3D.I. Mendeleev University of Chemical Technology of Russia, Moscow, Russia A method for producing new generation of xenogenic biomatrixes, which are characterized by their special purity and suitable for implantation in a living organism, is proposed by additional treatment with supercritical carbon dioxide. The obtained highly pure biomatrixes were modified by introducing dosed amounts of polylactides with a molecular weight of 20 and 40 KDa into their pore space. In vivo testing of the obtained materials showed their high biocompatibility with varying degrees of integration with surrounding tissues.

Key words: supercritical carbon dioxide, biological matrix, xenogenic bone tissue, resorbability, polylactide

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