Supercritical antisolvent precipitation of levofloxacin hydrochloride from single-phase and two-phase mixtures of CO₂—dimethylformamide

2023, №3

сс. 39-50

A.M. Vorobei, Y.P. Rubtsov, Y.I. Zuev, O.O. Parenago

Key words: supercritical antisolvent precipitation, morphology, crystallization, phase equilibria

The effect of pressure on the size and morphology of levofloxacin hydrochloride particles precipitated by supercritical antisolvent precipitation (SAS) was investigated. It is shown that the crystallization of levofloxacin from the two-phase CO₂—dimethylforamide—levofloxacin hydrochloride system leads to the production of particles with a bimodal size distribution. Crystallization from a single-phase system leads to a change in the mixing mode of CO2 and solution, and as a result, preci pitation of particles with a monomodal size distribution is observed. Liquid—gas equilibrium curves were obtained for the CO₂— dimethylforamide—levofloxacin hydrochloride system at a temperature of 40°C.

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doi:10.34984/SCFTP.2023.18.3.004

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ГОСТ
7.0.100-2018

Воробей, А.М. Supercritical antisolvent precipitation of levofloxacin hydrochloride from single-phase and two-phase mixtures of CO₂—dimethylformamide / А.М. Воробей, Я.П. Рубцов, Я.И. Зуев [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2023. – Т. 18. – № 3. – С. 39-50. - DOI: 10.34984/SCFTP.2023.18.3.004

TRANSLIT

Vorobej, A.M. Sverhkriticheskoe antisolventnoe osazhdenie gidrohlorida levofloksacina iz odnofaznoj i dvuhfaznoj smesej SO₂—dimetilformamid / A.M. Vorobej, Ya.P. Rubcov, Ya.I. Zuev [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2023. – Т. 18. – № 3. – S. 39-50. - DOI: 10.34984/SCFTP.2023.18.3.004

A.M. Vorobei, Y.P. Rubtsov, Y.I. Zuev, O.O. Parenago Supercritical antisolvent precipitation of levofloxacin hydrochloride from single-phase and two-phase mixtures of CO₂—dimethylformamide. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 3, 39-50 (2023). https://doi.org/10.34984/SCFTP.2023.18.3.004

Supercritical antisolvent precipitation of levofloxacin hydrochloride from single-phase and two-phase mixtures of CO2—dimethylformamide

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Supercritical antisolvent precipitation of levofloxacin hydrochloride from single-phase and two-phase mixtures of CO₂—dimethylformamide