Key words: supercritical fluids, nanoparticles, microparticles, pharmaceutical substances, liposomes
The preferences of drugs on the base of nano- and microparticles are reviewed in
comparison with traditional drug forms. The application of supercritical fluids for the
production of nano- and microforms of pharmaceutical substances including drug
delivery systems on the base of polymers and liposomes is discussed. The methods
based upon the use of supercritical fluids, such as RESS, GAS, ASES, SAS, SEDS were
shown to be of the most value for the production of nano- and microforms of drugs.
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7.0.100-2018
The Use of Supercritical Fluids for The Production of Nano- and Microforms of Pharmaceutical Substances / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 1. – С. 5-23. - DOI:
TRANSLIT
Okislitel'naya konversiya nizshih alkanov v sverhkriticheskih usloviyah: pervye rezul'taty, problemy, perspektivy / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 1. – S. 5-23. - DOI:
En
The Use of Supercritical Fluids for The Production of Nano- and Microforms of Pharmaceutical Substances. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 1, 5-23 (2008). https://doi.org/
Key words: supercritical fluids, microparticles, nanoparticles, chitosan
Micro- and nanoparticles of five chitosan derivatives were obtained for the first time
using Supercritical Assisted Atomization (SAA) method. The investigation of obtained
disperse chitosan forms using optical and scanning electron microscopies (SEM) and
particle size distribution technique demonstrated their uniformity. Depending on the
experimental conditions, particle size varies in the range of 0,3÷5 mm. It was concluded
that SAA method can be efficiently used for micronization of various chitosan
derivatives.
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7.0.100-2018
Formation of Micro- and Nanoparticles of Chitosan and Its Derivatives via Supercritical Assisted Atomization (SAA) / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 1. – С. 24-33. - DOI:
TRANSLIT
Poluchenie mikro- i nanochastic hitozana i ego proizvodnyh raspyleniem iz rastvorov s ispol'zovaniem sverhkriticheskih rastvoritelej / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 1. – S. 24-33. - DOI:
En
Formation of Micro- and Nanoparticles of Chitosan and Its Derivatives via Supercritical Assisted Atomization (SAA). Sverhkriticheskie Flyuidy: Teoriya i Praktika, 1, 24-33 (2008). https://doi.org/
Key words: polymer microparticles, encapsulation of bioactive components, supercritical carbon dioxide
The results of supercritical fluid synthesis of bioresorbable polymer microparticles
filled with bioactive plantain and calendula extracts are presented and discussed. The
process is based on spraying of the mixture of amorphous aliphatic polyester (D,Llactide)
plasticized by supercritical carbon dioxide with fine-dispersed plant extract
powder into low-pressure receiver through specific nozzle. Kinetics of extract release
from microparticles produced under different CO2 pressures is analyzed. The rate of
extract release into physiological solution depends on both carbon dioxide pressure
and initial polymer/extract ratio.
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7.0.100-2018
Fabrication of Biodegradable Microparticles
Comprising Bioactive Components
Using
Supercritical Carbon Dioxide
/
–
Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика..
–
2008.
– Т. 3. – № 1.
– С.
34-42.
- DOI:
TRANSLIT
Poluchenie biodegradiruemyh mikrochastic s bioaktivnymi komponentami s pomoshch'yu cverhkriticheskogo dioksida ugleroda / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 1. – S. 34-42. - DOI:
En
Fabrication of Biodegradable Microparticles
Comprising Bioactive Components
Using
Supercritical Carbon Dioxide.
Sverhkriticheskie Flyuidy: Teoriya i Praktika,
1,
34-42
(2008).
https://doi.org/
Key words: RESS, supercritical fluid, modeling, microparticles, anthracene
RESS process can be described in the framework of one-dimensional model, which
allows one to qualitatively analyzed the nucleation. The effects of supercritical solvent
density and of expansion device geometry onto the size of microparticles formed in
RESS process are examined.
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7.0.100-2018
Effects of Solvent Density and Channel Geometry onto Morphology and Size of Microparticles Formed During Rapid Expansion of Supercritical Solution (RESS) / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 1. – С. 43-49. - DOI:
TRANSLIT
Vliyanie plotnosti rastvoritelya i geometrii kanala na morfologiyu i razmer poluchaemyh mikrochastic v processe bystrogo rasshireniya sverhkriticheskogo rastvora / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 1. – S. 43-49. - DOI:
En
Effects of Solvent Density and Channel Geometry onto Morphology and Size of Microparticles Formed During Rapid Expansion of Supercritical Solution (RESS). Sverhkriticheskie Flyuidy: Teoriya i Praktika, 1, 43-49 (2008). https://doi.org/
Key words: nanoparticles, supercritical СО2, impregnation, olygouretanmetacrilate, optical spectroscopy, UV irradiation
Synthesis of Ag nanoparticles in the matrix of cross-linked olygouretanmetacrilate
(OUM) impregnated with Ag(fod) molecules (fod = 6,6,7,7,8,8,8-heptafluor-2,2-dimethyl-3,5-octadionate) dissolved in supercritical carbon dioxide and ethanol was
studied using absorption spectroscopy and scanning electron microscopy. Size
distribution and concentration of Ag nanoparticles synthesized in polymer matrix is
controlled by polymer structure, solvent type and by processing conditions. Treatment
with hydrogen and UV irradiation of OUM samples impregnated with Ag(fod), causes
both significant rise of Ag nanoparticles concentration and particles size in polymer
matrix. The new approach to fabrication of optical structures (including microstructures)
from nanoparticles in polymers is suggested, based on combination of
polymer samples impregnation and UV irradiation.
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7.0.100-2018
Synthesis of Ag Nanoparticles in the Matrix of Croos-Linked Olygouretanmetacrilate / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 1. – С. 50-58. - DOI:
TRANSLIT
Sintez nanochastic serebra v matrice sshitogo oligouretanmetakrilata / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 1. – S. 50-58. - DOI:
En
Synthesis of Ag Nanoparticles in the Matrix of Croos-Linked Olygouretanmetacrilate. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 1, 50-58 (2008). https://doi.org/
Key words: : polymers, Eu(Fod)3, photoluminescence, supercritical impregnation, water molecules, temperature bleaching of luminescence
The effects of temperature and humidity on optical properties of transparent polymers
impregnated with Eu(Fod)3 molecules (fod = 6,6,7,7,8,8,8-heptafluor-2,2-dimethyl-
3,5-octadionate) using supercritical carbon dioxide were studied. Two bands of
Eu(Fod)3 spectra both in polycrystalline phase and in polymer matrix are revealed,
related to two different forms of these molecules. To explain the observed degradation
of absorption and photoluminescence spectra of polypropylene film impregnated with
Eu(Fod)3, the model of atmospheric H2O interaction with Eu(Fod)3 molecules in
polymeric matrix was suggested. The effects of reversible temperature bleaching of
Eu3+ luminescence was observed and discussed in the context of fabrication of
temperature sensor.
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7.0.100-2018
Optical Properties of Transparent Polymers, Impregnated with Eu(Fod)3 Molecules Using Supercritical Carbon Dioxide / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 1. – С. 59-66. - DOI:
TRANSLIT
Opticheskie harakteristiki prozrachnyh polimerov, impregnirovannyh Eu(fod)3 s pomoshch'yu sverhkriticheskogo dioksida ugleroda / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 1. – S. 59-66. - DOI:
En
Optical Properties of Transparent Polymers, Impregnated with Eu(Fod)3 Molecules Using Supercritical Carbon Dioxide. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 1, 59-66 (2008). https://doi.org/
Key words: adiabatic calorimeter, aqueous solution, coexistence curve, critical amplitude, critical point, ethanol, equation of state, isochoric heat capacity, partial molar volume, supercritical water, water
Isochoric heat capacity of binary mixture (0.1446) H2O + (0.8554) C2H5OH have been
measured in the sub- and supercritical conditions with a high-temperature adiabatic
and nearly constant-volume calorimeter. Measurements of CV were performed as a
function of temperature along various near-critical isochores in the range from 234.8
to 391.1 kg·m-3 at temperatures between 439.3 and 521.5 K. In total 16 isochores — 4 vapor and 12 liquid, have been studied. The coverage includes the one- and twophase
regions near the liquid.gas coexistence curve at the sub- and the supercritical parameters of state. The uncertainty of isochoric heat capacity, density, and temperature
measurements was estimated to be less than 2÷3 %, 0.05 %, and 15 mK, respectively. The
values of temperature at coexistence curve, TS(ρ), for each measured densities (isochores)
were determined in calorimetric experiment using a quasi-static thermogram
technique supplemented by the sensor of adiabatic control. Using the measured values
of heat capacity (CVS), temperature (TS) and density
(ρS) on the coexistence curve
near the critical point (CP) the values of the critical parameters (TC,
ρC) for the
mixture (0.1446 m.f.) H2O + (0.8554 m.f) C2H5OH were determined. The measured
values of CV and TS, ρS for the saturated liquid and vapor have been analyzed and
interpreted in terms of extended scaling theory to accurately calculate the values of
the asymptotical critical amplitude (A0± and B0) of the power laws and in theory of
isomorphism of the critical phenomena in binary mixtures. The values of the
characteristic parameters (K1, K2, τ1, τ2, &Delta&rho1, &Delta&rho2)
of the mixture were estimated by using
the critical-curve data for H2O + C2H5OH mixture. It was shown that the heat capacity
of the mixture (o = 0.8554 m.f. C2H5OH or 96% by volume) near the CP behave just
like of CV for pure fluid. The same behavior of CV for this mixture was also predicted
from the analysis of the critical line behavior.
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7.0.100-2018
Isochoric Heat Capacity of Binary Mixture H2O—C2H5OH in the Sub- and Supercritical Conditions / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 1. – С. 67-90. - DOI:
TRANSLIT
Izohornaya teploemkost' binarnoj sistemy H2O—C2H5OH v do- i sverhkriticheskih usloviyah / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 1. – S. 67-90. - DOI:
En
Isochoric Heat Capacity of Binary Mixture H2O—C2H5OH in the Sub- and Supercritical Conditions. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 1, 67-90 (2008). https://doi.org/
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7.0.100-2018
A Brief Review on the Applications of Supercritical Fluid Chromatography (SFC) Mass Spectrometry (MS) / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 1. – С. 91-102. - DOI:
TRANSLIT
Kratkij obzor prilozhenij cverhkriticheskoj flyuidnoj hromatografii (SFH) mass-spektrometrii (MS) / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 1. – S. 91-102. - DOI:
En
A Brief Review on the Applications of Supercritical Fluid Chromatography (SFC) Mass Spectrometry (MS). Sverhkriticheskie Flyuidy: Teoriya i Praktika, 1, 91-102 (2008). https://doi.org/
Key words: green Vietnamese tea, supercritical carbon dioxide, tea leaves consumer qualities, de-coffeinization
The effect of suggested procedures - circulation of supercritical (SC) carbon dioxide
and periodical decompression in the system «initial raw material - SC-CO2» - of tea
leaves treatment onto the subsequent extraction of target components by hot water.
Some thermodynamic characteristics of SC fluid de-coffeinization process, as applied
to green Vietnamese tea, are investigated.
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ГОСТ
7.0.100-2018
Utilization Of Supercritical Carbon Dioxide for Improvement of Consumer Quality and Economical Production of Green Vietnamese Tea / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 2. – С. 7-19. - DOI:
TRANSLIT
Ispol'zovanie sverhkriticheskogo dioksida ugleroda dlya uluchsheniya potrebitel'skih svojstv i ekonomicheskih pokazatelej proizvodstva zelenogo v'etnamskogo chaya / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 2. – S. 7-19. - DOI:
En
Utilization Of Supercritical Carbon Dioxide for Improvement of Consumer Quality and Economical Production of Green Vietnamese Tea. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 7-19 (2008). https://doi.org/
Key words: supercritical extraction, oil-bearing crop seeds, mathematical modeling
A simplified mathematical model of ground oil-bearing crop seeds extraction is developed. It is reduced to a hyperbolic system of two equations related to the main process characteristics: (a) oil concentration in the fluid in microscopic channels of the granular layer of seed particles and (b) a fraction of initial oil reserve extracted from particles. Corresponding task is solved analytically. The solution is shown to have a structure of a running wave propagating at a constant velocity. The applicability of the model to the simulation of real extraction processes is confirmed by testing based on available experimental data.
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7.0.100-2018
Mathematical Model of Oil-Bearing Crop Seeds Extraction by Supercritical Carbon Dioxide / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 2. – С. 20-32. - DOI:
TRANSLIT
Matematicheskaya model' ekstragirovaniya semyan maslichnyh kul'tur sverhkriticheskim dioksidom ugleroda / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 2. – S. 20-32. - DOI:
En
Mathematical Model of Oil-Bearing Crop Seeds Extraction by Supercritical Carbon Dioxide. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 20-32 (2008). https://doi.org/
Key words: sub-critical water, quercetin, extraction
The method of quercetin extraction from plant raw materials in sub-critical water
medium is developed. It is more efficient than conventional extraction by polar organic
solvents (e.g. methanol) and does not require the use of environmentally non-friendly
solvents.
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7.0.100-2018
Bioflavonoid-Quercetin Extraction from Plant Raw Materials in Sub-critical Water Medium / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 2. – С. 33-36. - DOI:
TRANSLIT
Izvlechenie bioflavonoida-kvercetina iz rastitel'nogo syr'ya v srede subkriticheskoj vody / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 2. – S. 33-36. - DOI:
En
Bioflavonoid-Quercetin Extraction from Plant Raw Materials in Sub-critical Water Medium. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 33-36 (2008). https://doi.org/
Key words: sub-critical water, dihydroquercetin, extraction
The method of dihydroquercetin extraction from larch wood by sub-critical water is
developed. It is more efficient than conventional extraction by polar organic solvents
(e.g. acetone) and does not require the use of environmentally non-friendly solvents.
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7.0.100-2018
Dihydroquercetin Extraction from Larch Wood by Sub-Critical Water / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 2. – С. 37-42. - DOI:
TRANSLIT
Razrabotka metodiki ekstrakcii digidrokvercetina iz drevesiny listvennicy v srede subkriticheskoj vody / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 2. – S. 37-42. - DOI:
En
Dihydroquercetin Extraction from Larch Wood by Sub-Critical Water. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 37-42 (2008). https://doi.org/
Key words: Eucalyptus viminalis Labill., supercritical fluid CO2-extract, essential oil, chemical composition, monoterpens, sesquiterpens, phenoloaldehyds, Eucaliminum, Chlorophylliptum
A phytochemical comparison of essential oil and supercritical fluid CO2- extract (SCF-NI2-extract), and analysis of residues obtained from the leaves of eucalyptus (Eucalyptus viminalis Labill.) are performed. Compositions of essential oil and SCF-CO2-extract are similar qualitatively, but significantly differ in relative amounts of their main components. SCF-CO2-extract contains substantial amounts of sesquiterpens in addition to essential oil. The residue remaining after the separation of lypophylic fraction is
found to be a source of phenoloaldehyds, which can serve as constituents of pharmaceuticals (Eucaliminum and Chlorophylli ptum). The properties of residues remaining after the SCF-CO2-extraction are more technically advantageous.
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ГОСТ
7.0.100-2018
Comparative Phytochemical Study оf The Essential Oil and The Supercritical Fluid CO2-Extract From Leaves of Eucalyptus Viminalis / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 2. – С. 43-51. - DOI:
TRANSLIT
Sravnitel'noe fitohimicheskoe issledovanie efirnogo masla i sverhkriticheskogo flyuidnogo CO2-ekstrakta iz list'ev evkalipta prutovidnogo / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 2. – S. 43-51. - DOI:
En
Comparative Phytochemical Study оf The Essential Oil and The Supercritical Fluid CO2-Extract From Leaves of Eucalyptus Viminalis. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 43-51 (2008). https://doi.org/
Key words: : extraction, supercritical CO2, oil, heavy oil residues
The method for purification of oils and their heavy residues from asphaltenes and metals based on different solubilities of the main constituents of oil and its undesirable components in supercritical fluids (CO2). Effects of temperature, pressure and oil dilution with carbon dioxide, as well as tar dilution with light hydrocarbons and CO2 onto asphaltenes and metals removal are studied. The method provides with advanced purity of raw oil used further to produce final products (gasoline, base oils).
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7.0.100-2018
Purification of Oils and Their Heavy Residues from Asphaltenes and Metals by Supercritical Fluid Extraction Using Carbon Dioxide / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 2. – С. 52-57. - DOI:
TRANSLIT
Ochistka neftej i ih tyazhelyh ostatkov ot asfal'tenov i metallov sverhkriticheskoj flyuidnoj ekstrakciej s ispol'zovaniem dioksida ugleroda / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 2. – S. 52-57. - DOI:
En
Purification of Oils and Their Heavy Residues from Asphaltenes and Metals by Supercritical Fluid Extraction Using Carbon Dioxide. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 52-57 (2008). https://doi.org/
Key words: supercritical carbon dioxide, metal complex compounds, β-diketonates
Absorption spectra of silver and europium β-diketonates dissolved in supercritical
carbon dioxide and ethanol were studied. The structure of ligand UV absorption bands
was measured by different solvent types and temperature as well by intense UV irradiation
of solvent. The observed complex structure of ligand bands is treated by the formation
of molecular dimer and, also by the formation of hydrated form of β-diketonates. The
effect of silver nanoclasters synthesis under the action of UV radiation on ethanol
solution of silver β-diketonate was revealed, accompanied by the degradation of
ligand absorption band and formation of plasmon band at 420 nm.
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7.0.100-2018
Spectroscopy of Silver and Europium β-Diketonates Dissolved in Ethanol and Supercritical Carbon Dioxide / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 2. – С. 74-81. - DOI:
TRANSLIT
Spektroskopiya b-diketonatov serebra i evropiya v rastvorah etanola i sverhkriticheskogo dioksida ugleroda / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 2. – S. 74-81. - DOI:
En
Spectroscopy of Silver and Europium β-Diketonates Dissolved in Ethanol and Supercritical Carbon Dioxide. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 74-81 (2008). https://doi.org/
Key words: supercritical water, nanoparticles, indium oxide, zirconium dioxide, Lewis acidity
X-Ray diffraction, Raman and diffusion-reflectance absorption IR-spectroscopy are used to compare physical-chemical surface properties of In-Zr mixed nanocrystalline oxides, synthesized in supercritical water (SCW) and via conventional co-preci pitation technique. Samples synthesized in SCW have more stable surface properties. The basicity of mixed In-Zr oxides increases along with increasing In content.
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7.0.100-2018
Physical-Chemical Properties of Nanocrystalline Heterogeneous Catalysts In2O3-ZrO2 (3÷10 mol.% In2O3) Synthesized in Supercritical Water / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 2. – С. 82-92. - DOI:
TRANSLIT
Fiziko-himicheskie svojstva nanokristallicheskih geterogennyh katalizatorov In2O3-ZrO2 (3 ÷10 mol.% In2O3), prigotovlennyh v sverhkriticheskoj vode / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 2. – S. 82-92. - DOI:
En
Physical-Chemical Properties of Nanocrystalline Heterogeneous Catalysts In2O3-ZrO2 (3÷10 mol.% In2O3) Synthesized in Supercritical Water. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 82-92 (2008). https://doi.org/