Key words: supercritical carbon dioxide, synthetic matrix, carbonate-substituted hydroxyapatite, macroporosity, polyethylene glycol, resorbability, vancomycin, antibacterial substance, purulent-septic inflammation
A method for producing macroporous matrices based on carbonate-substituted hydroxyapatite containing vancomycin has been developed. The matrices combine bioresorbability, osteoconductivity, the possibility of volumetric impregnation of antibiotics without losing their activity and prolonging their release. In this work the technology for producing the matrix includes, as a final, stage of treatment with supercritical CO2. This makes it possible to completely remove the organic solvent — the extractant of the poreforming additive (polyethylene glycol granules), increasing the biocompatibility of the matrix, which is confirmed by the results of histological examination during subcutaneous implantation. The activity of vancomycin during its volumetric incorporation into the calcium phosphate matrix has been proven in the zones of inhibition of the growth of bacterial cultures. It has been proven in vivo experiments with bone implantation that the matrix is a therapeutically effective carrier of antibacterial substance for the treatment of purulent-septic inflammation of bone tissue.
doi:10.34984/SCFTP.2021.16.3.007