Chiral Separation of Salmeterol Isomers by Supercritical Fluid Chromatography

2021, №4

сс. 34-41

K.V. Gensh, V.N. Tsarev, I.V. Mikushina, N.G. Bazarnova.

Key words: salmeterol base, salmeterol xinafoate, supercritic fluid chromatography, enantiomers

The physicochemical features of the chiral separation of isomers of salmeterol xinafoate and salmeterol base were studied by supercritical fluid chromatography (SFC) in analytical and preparative modes. The influence of the composition of the mobile phase, temperature and pressure on retention, peak shapes and selectivity of chiral separation of the salmeterol base racemate in the analytical chromatography mode was studied. The optimal conditions for the separation of the enantiomers of salmeterol base on an analytical column Chiralpak IG in supercritical CO₂ (SC-CO₂) have been revealed. The behavior of salmeterol xinafoate was studied under conditions of preparative SFC analysis.

doi:10.34984/SCFTP.2021.16.4.004

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ГОСТ
7.0.100-2018

Геньш, К.В. Chiral Separation of Salmeterol Isomers by Supercritical Fluid Chromatography / К.В. Геньш, В.Н. Царев, И.В. Микушина. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2021. – Т. 16. – № 4. – С. 34-41. - DOI: 10.34984/SCFTP.2021.16.4.004

TRANSLIT

Gen'sh, K.V. Hiral'noe razdelenie izomerov salmeterola metodom sverhkriticheskoj flyuidnoj hromatografii / K.V. Gen'sh, V.N. Carev, I.V. Mikushina. – Tekst : neposredstvennyj // Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2021. – Т. 16. – № 4. – S. 34-41. - DOI: 10.34984/SCFTP.2021.16.4.004

K.V. Gensh, V.N. Tsarev, I.V. Mikushina, N.G. Bazarnova Chiral Separation of Salmeterol Isomers by Supercritical Fluid Chromatography. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 34-41 (2021). https://doi.org/10.34984/SCFTP.2021.16.4.004

Chiral Separation of Salmeterol Isomers by Supercritical Fluid Chromatography

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