Key words: acetylization, supercritical fluids, cellulose, acetic anhydride, cellulose diacetate
Possibility of cellulose acetylization by acetic anhydride in the supercritical carbon dioxide (SC-CO2) medium in the absence of traditional catalysts, toxic solvents and dilutants is demonstrated. As initial materials, three samples of cellulose were tested: sulfite and sulfate celluloses and cellulose obtained by low-temperature oxidative delignification in the SC-CO2 medium. Chemical composition of obtained cellulose diacetate is characterized.
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7.0.100-2018
Oxidative delignification of wood in the supercritical carbon dioxide medium.
4. Acetylization of cellulose in the supercritical carbon dioxide medium
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Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика..
–
2011.
– Т. 6. – № 4.
– С.
8-12.
- DOI:
TRANSLIT
Okislitel'naya delignifikaciya drevesiny v srede sverhkriticheskogo dioksida ugleroda. 4. Acetilirovanie cellyulozy v srede sverhkriticheskogo dioksida ugleroda / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2011. – Т. 6. – № 4. – S. 8-12. - DOI:
En
Oxidative delignification of wood in the supercritical carbon dioxide medium.
4. Acetylization of cellulose in the supercritical carbon dioxide medium.
Sverhkriticheskie Flyuidy: Teoriya i Praktika,
4,
8-12
(2011).
https://doi.org/
Key words: supercritical carbon dioxide, biomaterials, nano-scale hydroxyapatite, polylactide, selective laser sintering
Bioactive composites based on polylactide powders and nano-sized hydroxyapatite (HAP) for the production of three-dimensional scaffolds by selective laser sintering are manufactured using supercritical carbon dioxide. A mixture of powdered polymers and nano-sized HAP cannot be sintered directly by laser irradiation because continuous polymer filaments cannot be formed due to the absence of permanent contacts between polymer particles. This problem was resolved by employing for sintering composite polymer particles already containing HAP nanoparticles fabricated in the supercritical carbon dioxide medium. Mechanical tests and microscopy studies demonstrate that HAP particles are uniformly distributed in the sintered composites; the latter have no centers of destruction and withstand the same mechanical loads as pure polymer. Produced structures can be used as scaffolds in bone tissue engineering.
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Forming of bioactive material for selective laser sintering by homogenization of nano-hydroxyapatite with polylactide in supercritical carbon dioxide / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2011. – Т. 6. – № 4. – С. 13-21. - DOI:
TRANSLIT
Formirovanie bioaktivnogo materiala dlya selektivnogo lazernogo spekaniya iz smesi poroshkov nanogidroksiapatita i polilaktida v sverhkriticheskom diokside ugleroda / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2011. – Т. 6. – № 4. – S. 13-21. - DOI:
En
Forming of bioactive material for selective laser sintering by homogenization of nano-hydroxyapatite with polylactide in supercritical carbon dioxide. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 13-21 (2011). https://doi.org/
Key words: supercritical fluid chromatography, pharmaceuticals, preparative SFC, SFC/MS
Principals of supercritical fluid chromatography (SFC) and its application in various fields are reviewed. SFC is compared to high-performance liquid chromatography (HPLC). Fields of SFC application are considered. Special attention is paid to the analysis of pharmaceuticals (and their impurities), biologically active compounds and to the utilization of preparative SFC in the production of high purity compounds. Different types of detection in SFC are discussed; special attention is paid to the utilization of mass-spectrometric detectors in SFC.
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Supercritical fluid chromatography and its application to analysis and production of high purity compounds / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2011. – Т. 6. – № 4. – С. 22-50. - DOI:
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Cverhkriticheskaya flyuidnaya hromatografiya i ee primenenie v analize i poluchenii vysokochistyh veshchestv / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2011. – Т. 6. – № 4. – S. 22-50. - DOI:
En
Supercritical fluid chromatography and its application to analysis and production of high purity compounds. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 22-50 (2011). https://doi.org/
Key words: impurities in pharmaceuticals, generics, GC-MS, derivatization, supercritical fluid extraction, liquid extraction, atmospheric pressure photochemical ionization mass-spectrometry
The possibility of comparison of original pharmaceuticals and their generics, based on multidimensional profiles of impurities isolated from different samples by supercritical fluid extraction and liquid extraction and registered by gas-chromatography/mass-spectrometry with electron ionization (EI) and atmospheric pressure photochemical ionization (APPCI) is investigated. The utilization of the suggested approach allows one to increase of the number of registered impurities and, thus, to identify the authenticity of pharmaceutical samples and to compare the quality of original pharmaceuticals and their generics.
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7.0.100-2018
A new approach to the comparison of original pharmaceuticals and generics, based on comparison of multidimensional impurity profiles using supercritical fluid extraction, liquid extraction and GC-MS / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2011. – Т. 6. – № 4. – С. 51-58. - DOI:
TRANSLIT
Novyj podhod k sopostavleniyu original'nyh farmpreparatov i dzhenerikov, osnovannyj na sravnenii mnogomernyh profilej primesej s ispol'zovaniem SFE, ZHE i hromato-mass-spektrometrii / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2011. – Т. 6. – № 4. – S. 51-58. - DOI:
En
A new approach to the comparison of original pharmaceuticals and generics, based on comparison of multidimensional impurity profiles using supercritical fluid extraction, liquid extraction and GC-MS. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 51-58 (2011). https://doi.org/
Key words: supercritical water, brown coal, conversion, sulfur and oxygen removal
Conversion of brown coal in sub- and supercritical water at 310÷460 °C and pressures up to 30 MPa in the cyclic pressurization and depressurization modes is studied. The temperature dependences of coal organic matter (COM) conversion, yield of volatile and condensed products are obtained. Temperature dependence of condensed substances yield has a maximum at 370 °C. At rising temperature the fraction of high-molecular substances in condensed products is increased. Cumulative conversion of COM into volatile and condensed products at heating to 460 °С was correspondingly 31.4 and 8.6 %. According to the data of mass-spectrometric analysis of volatile products, elemental analysis of initial coal, carbonaceous residue after conversion and condensed products, 82.3 % of oxygen and 74.7 % of sulfur are removed from COM. The main products of conversion of oxygen and sulfur containing groups are CO2 and H2S.
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Conversion of brown coal in sub- and supercritical water at cyclic pressurization and depressurization / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2011. – Т. 6. – № 4. – С. 59-75. - DOI:
TRANSLIT
Konversiya burogo uglya v sub- i sverhkriticheskoj vode pri periodicheskom sbrose davleniya / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2011. – Т. 6. – № 4. – S. 59-75. - DOI:
En
Conversion of brown coal in sub- and supercritical water at cyclic pressurization and depressurization. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 59-75 (2011). https://doi.org/
Key words: supercritical drying equipment, polymer aerogel
A detailed explanation of manufacturing of installation for supercritical drying of polymer gels is presented. A special attention is paid to the preparation of moisture-free carbon dioxide . The effectiveness of constructed equipment is demonstrated on the examples of preparation of aerogel samples of given shape from organic polymers of different chemical compositions.
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Installation for supercritical drying: preparation, test run and resulting low-density polymer aerogels / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2011. – Т. 6. – № 4. – С. 76-87. - DOI:
TRANSLIT
Ustanovka dlya sverhkriticheskoj sushki: izgotovlenie, opyt raboty i poluchenie nizkoplotnyh polimernyh aerogelej / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2011. – Т. 6. – № 4. – S. 76-87. - DOI:
En
Installation for supercritical drying: preparation, test run and resulting low-density polymer aerogels. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 76-87 (2011). https://doi.org/
Key words: SCF micronization, risperidone, polymorphism
Comparative studies of supercritical fluid micro nization processes of 50-100 mm size risperidone pharmaceutical substrate using RESS and SAS approaches are performed to enhance its bioavailability in human body. Both micronization approaches allow obtaining risperidone microparticles of 5-20 mm size. SAS approach, however, is more preferable for effective risperidone micronization, since unlike RESS it doesn't cause any detectable contamination of risperidone with organic co-solvent residuals (used in these processes) and also allows obtaining risperidone microparticles of different shapes. It was revealed that SAS micronization process causes a change of risperidone polymorphous form from triclinic to monoclinic.
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Supercritical fluid micronization of risperidone / – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2011. – Т. 6. – № 4. – С. 88-102. - DOI:
TRANSLIT
Sverhkriticheskaya flyuidnaya mikronizaciya farmacevticheskoj substancii risperidon / – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2011. – Т. 6. – № 4. – S. 88-102. - DOI:
En
Supercritical fluid micronization of risperidone. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 88-102 (2011). https://doi.org/