2021, №2

сс. 24-32

Comparative Study of Levofloxacin Solubility in Supercritical Carbon Dioxide and Trifluoromethane

2021, №2

сс. 24-32

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E.N. Antonov, L.I. Krotova, G.V. Mishakov, V.K. Popov

Key words: levofloxacin, solubility, supercritical carbon dioxide, supercritical trifluoromethane

The solubility of levofloxacin (LFC) in supercritical carbon dioxide and trifluoromethane
was measured in the pressure range 10—30 MPa at temperatures of 323 K and 373 K.
Solubility was determined by changing the weight of the LFC powder held in the
supercritical fluid (SC) at given temperature and pressure. The obtained solubility value
of LFC in SC-trifluoromethane reaches a value (8.3 ± 0.3) · 10-5
mole fractions at 30 MPa and 373 K.
Solubility of LFC in SC-trifluoromethane at a pressure of 30 MPa and a
temperature of 323 K ((55.7 ± 0.3) · 10-6 mole fractions), almost by an order of magnitude
exceeds the solubility in SC carbon dioxide ((5.9 ± 0.3) · 10-6 under the same conditions.
The obtained results are the basis for further development and optimization of processes
of supercritical fluid micronization of LFC and other antibiotics of fluoroquinolone
group without partici pation of liquid co-solvent.

doi:10.1134/S1990793121080091