Chiral Separation of Salmeterol Isomers by Supercritical Fluid Chromatography

2021, №4

сс. 34-41

K.V. Gensh, V.N. Tsarev, I.V. Mikushina, N.G. Bazarnova

Key words: salmeterol base, salmeterol xinafoate, supercritic fluid chromatography, enantiomers

The physicochemical features of the chiral separation of isomers of salmeterol xinafoate
and salmeterol base were studied by supercritical fluid chromatography (SFC) in analytical
and preparative modes. The influence of the composition of the mobile phase, temperature
and pressure on retention, peak shapes and selectivity of chiral separation of the salmeterol
base racemate in the analytical chromatography mode was studied. The optimal conditions
for the separation of the enantiomers of salmeterol base on an analytical column Chiralpak IG
in supercritical CO₂ (SC-CO₂) have been revealed. The behavior of salmeterol
xinafoate was studied under conditions of preparative SFC analysis.

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ГОСТ
7.0.100-2018

Геньш, К.В. Chiral Separation of Salmeterol Isomers by Supercritical Fluid Chromatography / К.В. Геньш, В.Н. Царев, И.В. Микушина [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2021. – Т. 16. – № 4. – С. 34-41. - DOI: 10.34984/SCFTP.2021.16.4.004

TRANSLIT

Gen'sh, K.V. Hiral'noe razdelenie izomerov salmeterola metodom sverhkriticheskoj flyuidnoj hromatografii / K.V. Gen'sh, V.N. Carev, I.V. Mikushina [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2021. – Т. 16. – № 4. – S. 34-41. - DOI: 10.34984/SCFTP.2021.16.4.004

K.V. Gensh, V.N. Tsarev, I.V. Mikushina, N.G. Bazarnova Chiral Separation of Salmeterol Isomers by Supercritical Fluid Chromatography. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 34-41 (2021). https://doi.org/10.34984/SCFTP.2021.16.4.004

Chiral Separation of Salmeterol Isomers by Supercritical Fluid Chromatography

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