2010, №4

pp. 26-31

Asymmetric Hydrogenation of (E)-Dimethyl-2-Acetamido-2- Phenylvinylphosphonate in Supercritical Carbon Dioxide in the Presence of Metal Complexes with Phosphite-type Ligands

2010, №4

сс. 26-31

Quote

S.E. Lyubimov, E.A. Rastorguev, T.A. Verbitskaya, E.G. Rys, V.N. Kalinin, V.A. Davankov.

Key words: supercritical carbon dioxide, asymmetric hydrogenation, iridium complexes, aminophosphonates, amidophosphites

Asymmetric hydrogenation of (E)-dimethyl-2-acetamido-2-phenylvinylphosphonate is carried out in supercritical carbon (SC) dioxide and CH2Cl2 using Rh- and Ir-complexes with chiral phosphite-type ligands. It is demonstrated that Ir-catalysts dissolved in SC-CO2 provides with a high enantioselectivity (up to 98.5% ee) and high conversion. In the presence of Rh-catalysts only racemic product are formed.