Preparation of hydroxypropylmethylcellulose microparticles using supercritical antisolvent precipitation

2014, №4

сс. 3-11

A.M. Vorobei, K.B. Ustinovich, O.I. Pokrovskiy, O.O. Parenago, V.V. Lunin.

Key words: supercritical carbon dioxide, bioresorbable polymers, SCF-micronization, SAS, hydroxypropylmethylcellulose

Micronization of hydroxypropylmethylcellulose using supercritical antisolvent (SAS) method is studied. The influence of various parameters, such as solvent type, polymer concentration, pressure, solution to supercritical CO₂ flow rate ratio on morphology of particles is discussed. The possibility of obtaining spherical or elli ptical shape hydroxypropylmethylcellulose particles of submicron size (190-620 nm) that depends on the process parameters is demonstrated.

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ГОСТ
7.0.100-2018

Воробей, А.М. Preparation of hydroxypropylmethylcellulose microparticles using supercritical antisolvent precipitation / А.М. Воробей, К.Б. Устинович, О.И. Покровский [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2014. – Т. 9. – № 4. – С. 3-11.

TRANSLIT

Vorobej, A.M. Poluchenie mikrochastic gidroksipropilmetilcellyulozy metodom sverhkriticheskogo antisol'ventnogo osazhdeniya / A.M. Vorobej, K.B. Ustinovich, O.I. Pokrovskij [i dr.]. – Tekst : neposredstvennyj // Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2014. – Т. 9. – № 4. – S. 3-11.

A.M. Vorobei, K.B. Ustinovich, O.I. Pokrovskiy, O.O. Parenago, V.V. Lunin Preparation of hydroxypropylmethylcellulose microparticles using supercritical antisolvent precipitation. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 3-11 (2014). https://doi.org/

Preparation of hydroxypropylmethylcellulose microparticles using supercritical antisolvent precipitation

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