Key words: polymorphism, conformational equilibrium, supercritical fluids
In this work the investigation of the micronized forms of ibuprofen obtained by rapid expansion of supercritical fluid solution being at various temperatures in the range of 40—80 °C has been fulfilled. The results of scanning electron microscopy (SEМ), X-ray powder diffraction (RSA) and differential-scanning calorimetry (DSK) allowed coming to conclusion that the micronized form of ibuprofen obtained by RESS is the first polymorph with partially disturbed crystalline structure with comparison to the initial form. The defects of such structure may be the microinclusions of melted second polymorph. Moreover the molar fraction of these defects decreases with the increase of temperature of supercritical solution.
doi:10.34984/SCFTP.2018.13.4.001