Preparative Separation Method Development of Salbutamol Enantiomers by Supercritical Fluid Chromatography

2019, №4

сс. 19-26

I.V. Mikushina, V.N. Tsarev, N.G. Bazarnova, M.Yu. Cheprasova, A.V. Sysoeva, A.V. Sysoev, E.Yu. Kushnir, K.V. Gensh.

Key words: salbutamol, supercritical fluid chromatography, enantiomers, scaling method

The paper presents the results of scaling up the supercritical chiral separation of salbutamol to a preparative scale. Chromatographic conditions have been determined, a technique for preparative separation of enantiomers by supercritical fluid chromatography has been developed, in which the content of the R-isomer of salbutamol (enantiomeric purity) is not less than 90 %, the yield of the target product is more than 30%.

doi:10.34984/SCFTP.2019.14.4.003

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ГОСТ
7.0.100-2018

Микушина, И.В. Preparative Separation Method Development of Salbutamol Enantiomers by Supercritical Fluid Chromatography / И.В. Микушина, В.Н. Царев, Н.Г. Базарнова [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2019. – Т. 14. – № 4. – С. 19-26. - DOI: 10.34984/SCFTP.2019.14.4.003

TRANSLIT

Mikushina, I.V. Razrabotka metodiki preparativnogo razdeleniya enantiomerov sal'butamola metodom sverhkriticheskoj flyuidnoj hromatografii / I.V. Mikushina, V.N. Carev , N.G. Bazarnova [i dr.]. – Tekst : neposredstvennyj // Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2019. – Т. 14. – № 4. – S. 19-26. - DOI: 10.34984/SCFTP.2019.14.4.003

I.V. Mikushina, V.N. Tsarev, N.G. Bazarnova, M.Yu. Cheprasova, A.V. Sysoeva, A.V. Sysoev, E.Yu. Kushnir, K.V. Gensh Preparative Separation Method Development of Salbutamol Enantiomers by Supercritical Fluid Chromatography. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 4, 19-26 (2019). https://doi.org/10.34984/SCFTP.2019.14.4.003

Preparative Separation Method Development of Salbutamol Enantiomers by Supercritical Fluid Chromatography

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