Key words: impregnation, polymethylmethacrylate, carbamazepine, supercritical CO2
In this work we performed an impregnation of polymethylmethacrylate with carbamazepine in SC-CO2 medium. Impregnation was carried out at two temperatures of 75 °C and 105 °C and SC-CO2 density equal 1.3 of its critical value. In the first stage, in order to define the kinetic parameters of CO2 sorption by polymer matrix, we applied high pressure NMR spectroscopy. Two impregnated polymethylmethacrylate samples were obtained upon impregnation process and further they were analyzed by Raman spectroscopy and powder X-Ray diffraction. Basing on the results of Raman spectroscopy we found that both impregnated samples contain carbamazepine, at that its concentration in polymethylmethacrylate impregnated at 105 °C is in ∼2.7 times higher than in polymethylmethacrylate processed at 75 °C. It was also discovered that carbamazepine does not crystallize in the confinement of polymer matrix. Its solution in polymethylmethacrylate is formed instead. Moreover, processing temperature also affects on conformational state of carbamazepine molecules entrapped into polymer matrix.
doi:10.34984/SCFTP.2020.15.3.007