Determination of Spatial Structure and Preferred Conformations of Lidocaine in SC-CO₂ by 2D NOESY

2021, №2

сс. 63-72

K.V. Belov, A.A. Dyshin, M.G. Kiselev, M.A. Krestyaninov, V.V. Sobornova, I.A. Khodov.

Key words: high-pressure NMR, lidocaine, 2D NOESY, small molecules, DFT, spatial structure

The main goal of our research was to obtain information on the spatial structure of lidocaine in SC-CO₂. The preferred conformations of this compound in SC-CO₂ (at 70 °C, 20.0 MPa) were determined by two dimensional technique nuclear Overhauser effect spectroscopy (2D NOESY) and quantum chemistry calculation (DFT). This data can be used to calculation of parameters of state for micronization processing by RESS.

doi:10.34984/SCFTP.2021.16.2.008

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ГОСТ
7.0.100-2018

Белов, К.В. Determination of Spatial Structure and Preferred Conformations of Lidocaine in SC-CO<sub>2</sub> by 2D NOESY / К.В. Белов, А.А. Дышин, М.Г. Киселёв [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2021. – Т. 16. – № 2. – С. 63-72. - DOI: 10.34984/SCFTP.2021.16.2.008

TRANSLIT

Belov, K.V. Opredelenie prostranstvennoj struktury lidokaina v SK-SO2 metodom 2D NOESY / K.V. Belov, A.A. Dyshin, M.G. Kiselyov [i dr.]. – Tekst : neposredstvennyj // Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2021. – Т. 16. – № 2. – S. 63-72. - DOI: 10.34984/SCFTP.2021.16.2.008

K.V. Belov, A.A. Dyshin, M.G. Kiselev, M.A. Krestyaninov, V.V. Sobornova, I.A. Khodov Determination of Spatial Structure and Preferred Conformations of Lidocaine in SC-CO<sub>2</sub> by 2D NOESY. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 63-72 (2021). https://doi.org/10.34984/SCFTP.2021.16.2.008

Determination of Spatial Structure and Preferred Conformations of Lidocaine in SC-CO2 by 2D NOESY

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Determination of Spatial Structure and Preferred Conformations of Lidocaine in SC-CO₂ by 2D NOESY