Key words: cruciate ligament prosthesis, decellurization, supercritical fluid, biocompatible material, collagen frame, xenogenic materials
A prototype of a cruciate ligament (ACL) prosthesis from a lamb tendon was created. For the manufacture of this product, a raw material processing technology was developed, including mechanical and chemical-physical methods, including exposure to a supercritical fluid of carbon dioxide, with a nonionic surfactant Tween 80 for decellularization, that is, destruction of cells and extraction of their components with immunogenic properties, as well as the removal of residues of toxic substances after treatments, while maintaining the physical and mechanical properties. Histological studies were carried out for the remainder of cellular elements and measurements of the strength properties of the material and it was shown that the cells were removed, and the physical and mechanical properties did not deteriorate.
doi:10.34984/SCFTP.2021.16.4.008