2008, №1

сс. 24-33

Formation of Micro- and Nanoparticles of Chitosan and Its Derivatives via Supercritical Assisted Atomization (SAA)

2008, №1

сс. 24-33

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D.Yu. Zalepugin, A.I. Gamzazade, N.A. Tilkunova, V.S. Mishin, I.V. Chernyshova, A.R. Khokhlov

Key words: supercritical fluids, microparticles, nanoparticles, chitosan

Micro- and nanoparticles of five chitosan  derivatives were obtained for the first time
using Supercritical Assisted Atomization  (SAA) method. The investigation of obtained
disperse chitosan forms using optical and  scanning electron microscopies (SEM) and
particle size distribution technique  demonstrated their uniformity. Depending on the
experimental conditions, particle size  varies in the range of 0,3÷5  mm. It was concluded
that SAA method can be efficiently used for  micronization of various chitosan
derivatives.