Fabrication of Biodegradable Microparticles Comprising Bioactive Components
Using Supercritical Carbon Dioxide

2008, №1

сс. 34-42

E.N. Antonov, S.E. Bogorodski, B.M. Feldman, A.A. Markvicheva, L.D. Rumsh, V.K. Popov

Key words: polymer microparticles, encapsulation of bioactive components, supercritical carbon dioxide

The results of supercritical fluid  synthesis of bioresorbable polymer microparticles
filled with bioactive plantain and  calendula extracts are presented and discussed. The
process is based on spraying of the mixture  of amorphous aliphatic polyester (D,Llactide)
plasticized by supercritical carbon dioxide  with fine-dispersed plant extract
powder into low-pressure receiver through  specific nozzle. Kinetics of extract release
from microparticles produced under  different CO₂ pressures is analyzed. The rate of
extract release into physiological solution  depends on both carbon dioxide pressure
and initial polymer/extract ratio.

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ГОСТ
7.0.100-2018

Антонов, Е.Н. Fabrication of Biodegradable Microparticles Comprising Bioactive Components
Using Supercritical Carbon Dioxide / Е.Н. Антонов, С.Э. Богородский, Б.М. Фельдман [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2008. – Т. 3. – № 1. – С. 34-42.

TRANSLIT

Antonov, E.N. Poluchenie biodegradiruemyh mikrochastic s bioaktivnymi komponentami s pomoshch'yu cverhkriticheskogo dioksida ugleroda / E.N. Antonov, S.E. Bogorodskij, B.M. Fel'dman [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2008. – Т. 3. – № 1. – S. 34-42.

E.N. Antonov, S.E. Bogorodski, B.M. Feldman, A.A. Markvicheva, L.D. Rumsh, V.K. Popov Fabrication of Biodegradable Microparticles Comprising Bioactive Components
Using Supercritical Carbon Dioxide. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 1, 34-42 (2008). https://doi.org/

Fabrication of Biodegradable Microparticles Comprising Bioactive Components Using Supercritical Carbon Dioxide

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Fabrication of Biodegradable Microparticles Comprising Bioactive Components
Using Supercritical Carbon Dioxide