FTIR spectroscopy study of ibuprofen solubility in supercritical carbon dioxide

2012, №3

сс. 90-96

E.N. Antonov, S.A. Minaeva, V.K. Popov

Key words: FTIR spectroscopy, solubility in SCF, ibuprofen

A new approach to study the solubility of pharmaceutical substances in pressurized gases and supercritical (SC) media by FTIR spectroscopy is developed. The process of ibuprofen dissolution in supercritical carbon dioxide (SC-CO₂) in real time is studied. Two analytical IR-absorbance bands suitable for build-up of ibuprofen solubility calibration curves in SC-CO₂ are found. Saturation concentration (mole fraction) of ibuprofen in carbon dioxide at 35 °C and 15 MPa equal to (8,9±1,6)*10^-3 is determined.

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doi:10.1134/S199079311307004X

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ГОСТ
7.0.100-2018

Антонов, Е.Н. FTIR spectroscopy study of ibuprofen solubility in supercritical carbon dioxide / Е.Н. Антонов, С.А. Минаева, В.К. Попов. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2012. – Т. 7. – № 3. – С. 90-96.

TRANSLIT

Antonov, E.N. Issledovanie rastvorimosti ibuprofena v sverhkriticheskom diokside ugleroda metodom IK-Fur'e spektroskopii / E.N. Antonov, S.A. Minaeva, V.K. Popov. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2012. – Т. 7. – № 3. – S. 90-96.

E.N. Antonov, S.A. Minaeva, V.K. Popov FTIR spectroscopy study of ibuprofen solubility in supercritical carbon dioxide. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 3, 90-96 (2012). https://doi.org/

FTIR spectroscopy study of ibuprofen solubility in supercritical carbon dioxide

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