2012, №4

сс. 72-81

Sulfur-containing components of supercritical garlic extracts and their synthetic analogs as potential biocides

2012, №4

сс. 72-81

Цитировать

D.Yu. Zalepugin, N.A. Tilkunova, I.V. Chernyshova, A.L. Mulyukin

Key words: supercritical fluid extraction, carbon dioxide, garlic, extract, synthetic analogs, biocides

As we recently demonstrated, some individual component of CO2 supercritical (SC) garlic extract and some synthetic disulfide analogs are active as antimicrobials. In the course of this investigation six compounds (diallyl disulfide, 1-propenylallyl disulfide, methylallyl disulfide, diallyl trisulfide, 2-vinyl-4H-1,3-dithiin and 3-vinyl-4H-1,2-dithiin) were isolated from SC garlic extract and identified. Also, two novel sulfoxide-containing garlic analogs were synthesized. All isolated and synthetic substances were tested as potential antimicrobials against gram-positive bacteria Bacillus cereus, Mycobacterium smegmatis and Micrococcus luteus, аnd gram-negative bacteria Pseudomonas aurantiaca. Diallyl disulfide and diallyl trisulfide demonstrated the best activity both against gram- positive and gram-negative bacteria.

doi:10.1134/S1990793113070154