Formation of Injection Form Components of Prolonged Action Acetilsalicylic Acid Using Supercritical Carbon Dioxide

2016, №2

сс. 4-13

E.N. Antonov, S.E. Bogorodski, L.I. Krotova, V.K. Popov, V.Yu. Belov, S.V. Kursakov, V.I. Sevastyanov

Key words: dosage forms of the prolonged action, polymeric microparticles, encapsulation of bioactive components, supercritical carbon dioxide, acetilsalicylic acid, kinetics of release, HPLC

The formation of fine-dispersed (10—100 μm) forms of bioresorbable ali phatic
polyesters containing acetilsalicylic acid (ASA) in therapeutic concentrations (up to
10 % wt.) from the supercritical carbon dioxide medium is studied. The procedure for
the production of the prolonged action injection forms of ASA is developed. The in
vitro kinetics of the ASA release from polylactide microparticles into the saline is
studied.

Translated article

doi:10.1134/S1990793117070028

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ГОСТ
7.0.100-2018

Антонов, Е.Н. Formation of Injection Form Components of Prolonged Action Acetilsalicylic Acid Using Supercritical Carbon Dioxide / Е.Н. Антонов, С.Э. Богородский, Л.И. Кротова [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2016. – Т. 11. – № 2. – С. 4-13.

TRANSLIT

Antonov, E.N. Formirovanie komponentov in"ekcionnoj formy acetilsalicilovoj kisloty prolongirovannogo dejstviya s pomoshch'yu sverhkriticheskogo dioksida ugleroda / E.N. Antonov, S.E. Bogorodskij, L.I. Krotova [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2016. – Т. 11. – № 2. – S. 4-13.

E.N. Antonov, S.E. Bogorodski, L.I. Krotova, V.K. Popov, V.Yu. Belov, S.V. Kursakov, V.I. Sevastyanov Formation of Injection Form Components of Prolonged Action Acetilsalicylic Acid Using Supercritical Carbon Dioxide. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 4-13 (2016). https://doi.org/

Formation of Injection Form Components of Prolonged Action Acetilsalicylic Acid Using Supercritical Carbon Dioxide

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