Key words: supercritical carbon dioxide, synthetic matrix, carbonate-substituted hydroxyapatite, macroporosity, polyethylene glycol, resorbability, vancomycin, antibacterial substance, purulent-septic inflammation
A method for producing macroporous matrices based on carbonate-substituted
hydroxyapatite containing vancomycin has been developed. The matrices combine
bioresorbability, osteoconductivity, the possibility of volumetric impregnation of antibiotics
without losing their activity and prolonging their release. In this work the technology for
producing the matrix includes, as a final, stage of treatment with supercritical CO2. This
makes it possible to completely remove the organic solvent — the extractant of the poreforming
additive (polyethylene glycol granules), increasing the biocompatibility of the
matrix, which is confirmed by the results of histological examination during subcutaneous
implantation. The activity of vancomycin during its volumetric incorporation into the
calcium phosphate matrix has been proven in the zones of inhibition of the growth of
bacterial cultures. It has been proven in vivo experiments with bone implantation that the
matrix is a therapeutically effective carrier of antibacterial substance for the treatment of
purulent-septic inflammation of bone tissue.