Micronization of levofloxacin hydrochloride by supercritical antisolvent deposition from single-phase and two-phase mixtures of CO₂—acetone

2022, №3

сс. 26-36

A.M. Vorobey, A.G. Fedorovsky, M.O. Kostenko, Ya.I. Zuev, O.O. Parenago

Key words: supercritical antisolvent deposition, crystallization, morphology, phase equilibria

The dependence of the size and morphology of levofloxacin hydrochloride particles (hereinafter referred to as levofloxacin) deposited by supercritical anti-solvent deposition (A) on the pressure and concentration of the micronized substance in solution is investigated. It is shown that the crystallization of levofloxacin from the two-phase CO₂-acetone-levofloxacin system leads to the production of particles with a bimodal size distribution. An increase in pressure causes a change in the deposition regime, and as a consequence, the crystallization of smaller particles. Liquid-gas equilibrium curves for the CO₂-acetone-levofloxacin system at a temperature of 40 °C were constructed for the first time.

doi:10.34984/ SCFTP.2022.17.3.004

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ГОСТ
7.0.100-2018

Воробей, А.М. Micronization of levofloxacin hydrochloride by supercritical antisolvent deposition from single-phase and two-phase mixtures of CO₂—acetone / А.М. Воробей, М.О. Костенко, А.Г. Федоровский [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2022. – Т. 17. – № 3. – С. 26-36.

TRANSLIT

Vorobey, A.M. Mikronizaciya gidrohlorida levofloksacina metodom sverhkriticheskogo antisol'ventnogo osazhdeniya iz odnofaznoj i dvuhfaznoj smesej co₂—aceton / A.M. Vorobey, A.G. Fedorovsky, M.O. Kostenko [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2022. – Т. 17. – № 3. – S. 26-36.

A.M. Vorobey, A.G. Fedorovsky, M.O. Kostenko, Ya.I. Zuev, O.O. Parenago Micronization of levofloxacin hydrochloride by supercritical antisolvent deposition from single-phase and two-phase mixtures of CO₂—acetone. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 3, 26-36 (2022). https://doi.org/

Micronization of levofloxacin hydrochloride by supercritical antisolvent deposition from single-phase and two-phase mixtures of CO2—acetone

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Micronization of levofloxacin hydrochloride by supercritical antisolvent deposition from single-phase and two-phase mixtures of CO₂—acetone