Key words: supercritical antisolvent, morphology, crystallization, solubility
A new method for measuring the solubility of multicomponent fluids, based on a combination of supercritical antisolvent preci pitation and UV-spectroscopy (SAS—UFS), was proposed. Using acetylsalicylic acid as an example, the results of the solubility measurements obtained using this method were compared with literature data. The data on the solubility of acetylsalicylic acid obtained using the SAS—UFS technique are generally consistent with literature values: the order of values is the same under all conditions. In most cases, the values obtained using the SAS—UFS technique fall within the range of values obtained using other methods, such as the dynamic method and SAS—SFC (combination of supercritical antisolvent precipitation and supercritical fluid chromatography). These results indirectly indicate the accuracy of the data obtained.
doi:10.1134/S1990793125701234