Key words: supercritical antisolvent, crystallization, morphology
The study investigates the dependence of the size and morphology of salbutamol sulfate particles preci pitated by supercritical antisolvent preci pitation (SAS) on the pressure and concentration of the micronized substance in solution. It is shown that micronization by the SAS method from single-phase and two-phase methanol—CO2—salbutamol sulfate systems results in the production of amorphous spherical particles and crystalline particles elongated in one direction, respectively. When the process is carried out from a singlephase system, particles of significantly smaller size are observed compared to those obtained from the two-phase region. Additionally, during micronization from both two-phase and single-phase systems, different dependences of particle size on the concentration of salbutamol in the solution are observed using the SAS method. The main reason for these differences is related to the mechanisms of mixing of the solvent with the solution. In the case of a two-phase system, crystallization occurs in droplets, which have a significantly higher proportion of solvent compared to a single-phase system. This leads to a lower local degree of supersaturation.
doi:10.1134/S1990793125701246