Key words: subcritical water, agro-industrial complex wastes, buckwheat husk, polyphenols, anti-acetylcholinesterase activity
The effect of the extraction method and conditions on polyphenol composition of buckwheat (Fagopyrum esculentum) husk extracts and their acetylcholinesterase (AChE) inhibition activity was studied. The extracts were obtained both by the traditional method of water-ethanol extraction and in a subcritical water (SBW) medium at 120—220 °C. A direct correlation was found between anticholinesterase activity and the content of polyphenols in the extracts. The highest activity in inhibiting AChE was demonstrated by the extract obtained in the SBW medium at 220 °C, which contains the maximum amounts of the sum of polyphenols and flavonoids. This indicates the decisive role of these compounds in AChE inhibition. The obtained data allow us to consider such extracts as inexpensive and renewable sources of polyphenolic compounds and flavonoids with P-vitamin and neuroprotective activity.
doi:10.34984/SCFTP.2024.19.3.006