Synthesis of Glycyrrhetinic Acid via Hydrolysis of Licorice Root Extract in Subcritical Water Medium

2010, №2

сс. 21-27

K.S. Tikhomirova, A.V. Lekar, S.N. Borisenko, E.V. Vetrova, N.I. Borisenko, V.I. Minkin

Key words: subcritical water, triterpene glycosides, glycyrrhetinic acid (the aglycon of glycyrrhizic acid), licorice root, high-performance liquid chromatography (HPLC), ¹³С NMR spectroscopy

A method for glycyrrhetinic acid (the aglycon of glycyrrhizic acid) synthesis via a sub-critical water hydrolysis of licorice root extract is developed. Its high efficiency in the comparison with a conventional hydrolysis is demonstrated. The high-performance liquid chromatography is used to prove the presence of glycyrrhetinic acid and to determine its concentration in the product. Using the ¹³С NMR spectroscopy it is proved that glycyrrhetinic acid obtained in the sub-critical water medium has a β-configuration in theС₁₈ carbon atom environment.

Translated article

doi:10.1134/S1990793110070122

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ГОСТ
7.0.100-2018

Тихомирова, К.С. Synthesis of Glycyrrhetinic Acid via Hydrolysis of Licorice Root Extract in Subcritical Water Medium / К.С. Тихомирова, А.В. Лекарь, С.Н. Борисенко [и др.]. – Текст : непосредственный // Сверхкритические Флюиды: Теория и Практика.. – 2010. – Т. 5. – № 2. – С. 21-27.

TRANSLIT

S., K. Poluchenie glicirretinovoj kisloty gidrolizom ekstrakta kornya solodki v srede subkriticheskoj vody / K. S. Tihomirova, A. V. Lekar', S. N. Borisenko [i dr.]. – Sverhkriticheskie Flyuidy: Teoriya i Praktika.. – 2010. – Т. 5. – № 2. – S. 21-27.

K.S. Tikhomirova, A.V. Lekar, S.N. Borisenko, E.V. Vetrova, N.I. Borisenko, V.I. Minkin Synthesis of Glycyrrhetinic Acid via Hydrolysis of Licorice Root Extract in Subcritical Water Medium. Sverhkriticheskie Flyuidy: Teoriya i Praktika, 2, 21-27 (2010). https://doi.org/

Synthesis of Glycyrrhetinic Acid via Hydrolysis of Licorice Root Extract in Subcritical Water Medium

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