Key words: supercritical carbon dioxide, bone tissue engineering, composites, nano-scale hydroxyapatite, polylactide, mechanical properties
Composite materials for biomedical applications based on bioresorbable polymer and nano-sized calcium phosphates (hydroxyapatite) are prepared using supercritical carbon dioxide. The stress-strain while bending dependence are investigated for the composites with different ratios of polymer and mineral parts. The elastic modulus of composites obtained in supercritical conditions from bioresorbable polymer and bioactive nanoceramics were in the range of elastic modulus of natural bone tissues. Experiments on human embryonic fibroblasts demonstrated the suitability of sintered samples for using in tissue engineering and regenerative medicine.
doi:10.1134/S1990793111080033