2011, №4

сс. 13-21

Forming of bioactive material for selective laser sintering by homogenization of nano-hydroxyapatite with polylactide in supercritical carbon dioxide

2011, №4

сс. 13-21

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E.N. Antonov, S.A. Bochkova, A.V. Popova

Key words: supercritical carbon dioxide, biomaterials, nano-scale hydroxyapatite, polylactide, selective laser sintering

Bioactive composites based on polylactide  powders and nano-sized hydroxyapatite (HAP) for the production of  three-dimensional scaffolds by selective laser sintering are manufactured using  supercritical carbon dioxide. A mixture of powdered polymers and nano-sized HAP  cannot be sintered directly by laser irradiation because continuous polymer  filaments cannot be formed due to the absence of permanent contacts between polymer  particles. This problem was resolved by employing for sintering composite  polymer particles already containing HAP nanoparticles fabricated in the  supercritical carbon dioxide medium. Mechanical tests and microscopy studies  demonstrate that HAP particles are uniformly distributed in the sintered  composites; the latter have no centers of destruction and withstand the same  mechanical loads as pure polymer. Produced structures can be used as scaffolds  in bone tissue engineering.

doi:10.1134/S1990793111080045