Key words: antidote against carbon monoxide, acizol, supercritical carbon dioxide, controllable drug release
Encapsulation of pharmaceutical grade acizol into bioresorbable D,L-polylactide and
polylactoglycolide microparticles using supercritical carbon dioxide is studied. An
effective way for fabrication of polymer fine powders (mean particle size ca. 10—20
μm) containing up to 20 % wt. of bioactive component without any organic solvent is
suggested. Raman spectroscopy with spatial resolution is employed to analyze the
distribution of acizol throughout the volume of individual polymer microparticles
and kinetics of its release into the saline solution. A steep release (ca. 40—80% of the
total amount of encapsulated substance) from the samples under study during the
first hour followed by gradual, almost linear release between fourth and fourteenth
days of experiment with cumulative outcome of up to 100% is observed.
doi:10.1134/S1990793115070052