Key words: supercritical antisolvent preci pitation, salbutamol, micronization, morphology, supersaturation degree
The applicability of the method of supercritical antisolvent preci pitation (SAS) to
obtain microparticles of an anti-asthmatic salbutamol sulfate preparation suitable for
the production of an inhalable dosage form is studied. Depending on the concentration
of salbutamol in the starting solution, its flow rate and the pressure, spherical or needle
shaped particles of 0.7 to 8.5 microns can be obtained. The dependence of the average
particle size on the concentration of salbutamol in the initial solution is nonmonotonic.
The conditions for the production of particles suitable in shape and size for the
inhalation dosage form are determined.
doi:10.1134/S1990793118080146