Key words: supercriticalcarbondioxide, biodegradablepolymers, substituteddiarylimidazoles, compositions with a slow release of the active substance, solubilization.
Compositions based on chitosan and substituted diarylimidazoles (DAI), which have
an antitumor effect, with a slow release of active substances have been obtained in the
SC-CO2 medium. It has been established that the use of water (0.17% by volume) as
a co-solvent during SCF-impregnation of chitosan with diarylimidazoles leads to an
increase in the content of DAI in the polymer matrices. Obviously, it is due to an
increase in the degree of chitosan swelling in the SC-CO2 medium in the presence of water.
It is interesting to note that the effect of water on the release rateof diarylimidazoles
from the polymer matrices into the model medium with pH 1.6 was determined by
the structure of diarylimidazoles. For the first time it has been shown that the
solubilization of DAI molecules by Pluronic F-127 before their SC-introduction into
the matrices of chitosan can be used as an additional effective method of prolonging
the action of matrix preparations.
doi:10.1134/S1990793119070248