Key words: supercritical carbon dioxide, electron paramagnetic resonance spectroscopy, polylactide, spin probe
For the first time, the EPR-method was used to quantitatively describe the process of
releasing a paramagnetic biologically active substance from a polymer biodegradable
matrix. A standard TEMPONE spin probe was chosen as the paramagnetic compound,
and D, L-polylactide foamed in supercritical carbon dioxide was used as the polymer.
It is shown that the release of TEMPONE from porous D, L-polylactide into phosphate
buffer with pH 7,4 occurs gradually, without periods of burst and stagnation, which
indicates that it is possible in principle to use the used technology of impregnation
and foaming of the polymer to create materials for medicalpurposes.
doi:10.1134/S199079311907025X