Key words: supercritical fluid technologies, bioresorbable scaffolds and microparticles, encapsulation of gentamicin and levofloxacin, kinetics of release into physiological media
Gentamicin and levofloxacin were encapsulated into bioresorbable polymer scaffolds
and microparticles by SCF methods — PGSS and plasticization and subsequent foaming
of amorphous polymers using supercritical carbon dioxide. Release kinetics of
incorporated drug substances into model physiological media was studied. It was shown
that the use of the developed methods of SCF-encapsulation of drugs in bioresorbable
carriers allows varying the size, shape and morphology of formed structures and
accordingly the rate of release of drugs into physiological environments. In our opinion,
this approach can be very promising for the development of components of new
highly effective antibacterial prolonged dosage forms.
doi:10.1134/S1990793120070027