2021, №4

сс. 42-55

Fluorinated Porphyrins Immobilized on Perfluorinated Copolymer MF-4SK in Supercritical Carbon Dioxide as Photosensitizers of Singlet Oxygen Generation In Biologically Active Substrates Oxidation

2021, №4

сс. 42-55

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I.V. Shershnev, A.S. Kopylov, A.V. Cherkasova, A.B. Solovieva

Key words: fluorinated tetraphenylporphyrins, MF-4SK copolymer, photosensitized cholesterol oxidation

The immobilization of fluorinated tetraphenylporphyrins in the matrix of the sulfocathionite
perfluorinated copolymer MF-4SK and the photosensitized oxidation of cholesterol in
the presence of obtained composite were carried out in the supercritical (SC) carbon
dioxide medium. It is shown that the reaction proceeds with the formation of
6-formyl-B-norcholestane-3β,5β-diol (a potential antitumor agent), in contrast to the homogeneous
photooxidation of cholesterol, where main product is 7α-hydroperoxide-3β-hydroxycholest-5-ene.
A reaction mechanism has been proposed, which assumes the process
takes place inside the «ion channels» of MF-4SK.