Key words: supercritical extraction, carbon dioxide, garlic, extract, disulfides, biocides
Garlic (Allium sativum L.) extracts were obtained using CO2-supercritical extraction. The extracts were separated into individual components by preparative HPLC and GC methods. Some of the isolated substances (allicin, diallyldisulfide, diallyltrisulfide) along with two synthetic analogs were tested as potential biocides using the following models: Candida utilis, Bacillus cereus, Pseudomonas aurantiaca, and Escherichia coli. Some of tested substances revealed high efficacy as biocides, in particular, against gram-negative cultures. The obtained results give evidence of good perspectives of sulfur-containing gar1ic components and their synthetic analogs as potential antimicrobial agents.
doi:10.1134/S1990793110070092